A typology for emergency department (ED) use was developed among persons with current or previous experience of homelessness in Quebec (Canada) (n = 455). Cluster analysis identified four profiles: (1) Low or high ED users in permanent housing: high use of primary care services; (2) High ED users in temporary housing or emergency shelters: complex health problems, frequent hospitalizations, without case managers; (3) Low or non-ED users in temporary housing: middle-aged, low quality of life, few chronic physical illnesses, little service use; and (4) Non-ED users in permanent housing: high quality of life, few affected by stigma, infrequent service use. Needs factors mainly accounted for ED use, but use of diversified health services and professionals reduced ED use. Results also suggested that improving access to health services may reduce stigma. Living in permanent housing and having a case manager were related to lower ED use, fewer hospitalizations, and greater satisfaction with services.